sonicc (second-order nonlinear optical imaging chiral crystals) microscope (Formulatrix)
90
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Formulatrix
sonicc (second-order nonlinear optical imaging chiral crystals) microscope
Sonicc (Second Order Nonlinear Optical Imaging Chiral Crystals) Microscope, supplied by Formulatrix, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sonicc+(second-order+nonlinear+optical+imaging+chiral+crystals)+microscope/sonicc++second+order+nonlinear+optical+imaging+of+chiral+crystals++microscope/us10309902-55-7-16
Average 90 stars, based on 1 article reviews
Sonicc (Second Order Nonlinear Optical Imaging Chiral Crystals) Microscope, supplied by Formulatrix, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sonicc+(second-order+nonlinear+optical+imaging+chiral+crystals)+microscope/sonicc++second+order+nonlinear+optical+imaging+of+chiral+crystals++microscope/us10309902-55-7-16
Average 90 stars, based on 1 article reviews
sonicc (second-order nonlinear optical imaging chiral crystals) microscope - by Bioz Stars,
2026-10
90/100 stars
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Optical Imaging:Article Title: Kinetic Modeling of Accelerated Stability Testing Enabled by Second Harmonic Generation Microscopy Article Snippet: The low limits of detection afforded by second harmonic generation (SHG) microscopy coupled with image analysis algorithms enabled quantitative modeling of the temperature-dependent crystallization of active pharmaceutical ingredients (APIs) within amorphous solid dispersions (ASDs).. ASDs, in which an API is maintained in an amorphous state within a polymer matrix, are finding increasing use to address solubility limitations of small-molecule APIs.. Extensive stability testing is typically performed for ASD characterization, the time frame for which is often dictated by the earliest detectable onset of crystal formation. Article Title: Second harmonic generation microscopy as a tool for the early detection of crystallization in spray dried dispersions. Article Snippet: Various techniques have been used to detect crystallization in amorphous solid dispersions (ASD).. However, most of these techniques do not enable the detection of very low levels of crystallinity (<1%).. The aim of the current study was to compare the sensitivity of second harmonic generation (SHG) microscopy with powder X-ray diffraction (XRPD) in detecting the presence of crystals in low drug loading amorphous solid dispersions. Article Title: Characterization of trace crystallinity by second harmonic generation microscopy Article Snippet: SHG images were acquired with a commercial Article Title: Finding the Needle in the Haystack: Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. Article Snippet: Second harmonic generation (SHG) microscopy was used to rapidly identify regions of interest for localized confocal Raman spectroscopy measurements in order to quantify crystallinity within lyophilized Abraxane powder (protein bound paclitaxel for injectable suspension).. Water insoluble noncentrosymmetric crystalline particles ranging from ∼1 to 120 μm were identified by SHG, with wide variability in crystal size and frequency observed between several batches of Abraxane.. By targeting the Raman analysis to these localized regions identified by SHG, the required measurement time was decreased over 2 orders of magnitude, from 8 h to 2 s. Experimental Raman spectra of SHG active domains in Abraxane were in good agreement with experimental spectra of pure crystalline paclitaxel. Microscopy:Article Title: Kinetic Modeling of Accelerated Stability Testing Enabled by Second Harmonic Generation Microscopy Article Snippet: The low limits of detection afforded by second harmonic generation (SHG) microscopy coupled with image analysis algorithms enabled quantitative modeling of the temperature-dependent crystallization of active pharmaceutical ingredients (APIs) within amorphous solid dispersions (ASDs).. ASDs, in which an API is maintained in an amorphous state within a polymer matrix, are finding increasing use to address solubility limitations of small-molecule APIs.. Extensive stability testing is typically performed for ASD characterization, the time frame for which is often dictated by the earliest detectable onset of crystal formation. Article Title: Second harmonic generation microscopy as a tool for the early detection of crystallization in spray dried dispersions. Article Snippet: Various techniques have been used to detect crystallization in amorphous solid dispersions (ASD).. However, most of these techniques do not enable the detection of very low levels of crystallinity (<1%).. The aim of the current study was to compare the sensitivity of second harmonic generation (SHG) microscopy with powder X-ray diffraction (XRPD) in detecting the presence of crystals in low drug loading amorphous solid dispersions. Article Title: Characterization of trace crystallinity by second harmonic generation microscopy Article Snippet: SHG images were acquired with a commercial Article Title: Finding the Needle in the Haystack: Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. Article Snippet: Second harmonic generation (SHG) microscopy was used to rapidly identify regions of interest for localized confocal Raman spectroscopy measurements in order to quantify crystallinity within lyophilized Abraxane powder (protein bound paclitaxel for injectable suspension).. Water insoluble noncentrosymmetric crystalline particles ranging from ∼1 to 120 μm were identified by SHG, with wide variability in crystal size and frequency observed between several batches of Abraxane.. By targeting the Raman analysis to these localized regions identified by SHG, the required measurement time was decreased over 2 orders of magnitude, from 8 h to 2 s. Experimental Raman spectra of SHG active domains in Abraxane were in good agreement with experimental spectra of pure crystalline paclitaxel. Modification:Article Title: Kinetic Modeling of Accelerated Stability Testing Enabled by Second Harmonic Generation Microscopy Article Snippet: The low limits of detection afforded by second harmonic generation (SHG) microscopy coupled with image analysis algorithms enabled quantitative modeling of the temperature-dependent crystallization of active pharmaceutical ingredients (APIs) within amorphous solid dispersions (ASDs).. ASDs, in which an API is maintained in an amorphous state within a polymer matrix, are finding increasing use to address solubility limitations of small-molecule APIs.. Extensive stability testing is typically performed for ASD characterization, the time frame for which is often dictated by the earliest detectable onset of crystal formation. Article Title: Second harmonic generation microscopy as a tool for the early detection of crystallization in spray dried dispersions. Article Snippet: Various techniques have been used to detect crystallization in amorphous solid dispersions (ASD).. However, most of these techniques do not enable the detection of very low levels of crystallinity (<1%).. The aim of the current study was to compare the sensitivity of second harmonic generation (SHG) microscopy with powder X-ray diffraction (XRPD) in detecting the presence of crystals in low drug loading amorphous solid dispersions. Article Title: Characterization of trace crystallinity by second harmonic generation microscopy Article Snippet: SHG images were acquired with a commercial Article Title: Finding the Needle in the Haystack: Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. Article Snippet: Second harmonic generation (SHG) microscopy was used to rapidly identify regions of interest for localized confocal Raman spectroscopy measurements in order to quantify crystallinity within lyophilized Abraxane powder (protein bound paclitaxel for injectable suspension).. Water insoluble noncentrosymmetric crystalline particles ranging from ∼1 to 120 μm were identified by SHG, with wide variability in crystal size and frequency observed between several batches of Abraxane.. By targeting the Raman analysis to these localized regions identified by SHG, the required measurement time was decreased over 2 orders of magnitude, from 8 h to 2 s. Experimental Raman spectra of SHG active domains in Abraxane were in good agreement with experimental spectra of pure crystalline paclitaxel. |